Thyroid Influence on Immunology

• Immune Regulation & Thyroid Hormones
• Hypothyroid states display lower T & B-cell mitogen-induced proliferation
• Hyperthyroid states display higher proliferation
• This demostates the importance of thyroid hormones in regulating lymphocyte reactivity.

Analysis of the ability of T3 to influence cytoplasmic-nuclear shuttling of nuclear factor-kappaB on primed dendritic cells have profound implications in immunopathology, including cancer and autoimmune manifestations of the thyroid gland SPECIFICALLY at the crossroads of the immune and endocrine systems.