It has been well established that neuronal, microglial, and astroglial cells are recognized targets of thyroid hormones.

• T4 & T3 thyroid hormones have been demonstrated to favor basic processes of
  • neurogenesis
  • precursor cell proliferation
  • neuronal migration
  • dendritic and axonal growth
  • myelination
  • synaptogenesis
• It is therefore possible that thyroid hormone deprivation would affect neurodevelopment. This connection is a probable epigenitic causation of childhood development spectrum disorders.